CRYPTOSPORIDIOSIS PROTECTION
THE IMPOSSIBLE IS
Now Possible


Introducing BOVILIS CRYPTIUM®, the long awaited vaccine designed to help reduce the impact of Cryptosporidium parvum “Crypto” in newborn calves.
For active immunisation of pregnant heifers and cows to raise antibodies in their colostrum against Gp40 of C. parvum, intended for passive immunisation of calves to aid in reducing clinical signs (i.e. diarrhoea) caused by C. parvum.


MSD Animal Health offers the broadest Calf Diarrhoea portfolio with Bovilis Cryptium, Rotavec® Corona and Halocur®

Available in 50 dose presentation with a shelf life of 28 days after first opening.
CONVENIENT & FLEXIBLE ADMINISTRATION

Bovilis Cryptium can be administered on the same day as Rotavec® Corona, at different injection sites.

These two vaccines together protect against the 4 of the most common Neonatal Calf Diarrhoea pathogens.
C. parvum, coronavirus, rotavirus, E. coli.
Bovilis Cryptium is a vaccine for subcutaneous administration.


Primary Course: 2 doses (SC), 12-3 weeks before calving, 4-5 weeks apart*.
Booster: 1 dose, 12-3 weeks before each subsequent calving*.
* vaccinations to be given in the third trimester of pregnancy.

Primary Course: 1 dose (SC or IM), 12-3 weeks before calving.
Booster: 1 dose, 12-3 weeks before each subsequent calving.
Rotavec® Corona can be given on the same day, with first or second vaccination of Bovilis Cryptium.
BOVILIS CRYPTIUM gives the immunity your herd needs from the start of life. The result is lower morbidity, higher weight gain and overall higher herd productivity.
COLOSTRUM
MANAGEMENT
Protection of calves depends on adequate ingestion of colostrum and transition milk from vaccinated cows and heifers.
Studies showed that supplemental colostrum feeding during the first 2 weeks reduces diarrhoea and improves average daily gain3.


LONGER COLOSTRUM FEEDING IS BENEFICIAL FOR IMMUNITY

Local immunity.

Development of intestinal villi.

Top Farmers Colostrum Management Video


Hear From
Our Expert
Listen to Dr. Mark van Roosmalen talk about Cryptosporidiosis and what the new Bovilis Cryptium vaccine will mean for farmers.

FAQs
Cryptosporidiosis is the disease caused by Cryptosporidium, a genus of microscopic gastrointestinal parasites that cause diarrhoea in many species, including humans. The specific species Cryptosporidium parvum is a significant cause of neonatal calf diarrhoea (scours).
Calves with cryptosporidiosis suffer from mild to severe diarrhoea, typically lasting several days. In some cases, they may also exhibit mild fever, dehydration, apathy, anorexia, and weight loss (short and long-term). While crypto is typically not fatal, management strategy can have a large impact on fatality rates.
Cryptosporidium is transmitted via the faecal-oral route, meaning that infection is caused when Cryptosporidium oocysts are ingested orally, and are spread through an infected animal’s faeces. Because of this, transmission can occur directly (from another infected calf, animal, or human), or indirectly (through faecal contamination in the immediate environment, water, feed, or fomites). This infection results in diarrhoea because the lifecycle of the parasite causes damage or disruption to the digestive system of the calf.
Cryptosporidiosis is primarily managed with supportive care (e.g., electrolyte therapy, fluids), but options like antibiotics, feed additives, or Halocur® can help. However, it is preferred to prevent the disease altogether through hygienic measures and vaccination with Bovilis Cryptium, and to reserve these treatments as a second-line defense.
Cryptosporidiosis can be avoided by implementing proper hygiene practices on the farm as well as using a robust vaccination schedule, including the use of Bovilis Cryptium, the first and only vaccine designed to protect newborn calves against cryptosporidiosis from day one.
No, Bovilis Cryptium is a vaccine. Antibiotics can be harmful to the gut microbiome, and their overuse can contribute to the rise of antibiotic resistance, so it is preferable to begin with preventative measures when managing diseases.
Bovilis Cryptium works by increasing the specific antibodies in the colostrum of the dam, which are then passed onto the calf when it consumes her colostrum. This provides the calf with protection against the parasite in the form of passive local immunity. Protection of calves depends on adequate ingestion of colostrum and transition milk from vaccinated mother cows. It is recommended that all calves are fed colostrum and transition milk during the first 5 days of life.
Talk to your vet to discuss implementing Bovilis Cryptium on your farm! Bovilis Cryptium is a convenient health solution that can be administered at the same time as Rotavec® Corona to provide comprehensive protection against the four most common neonatal calf diarrhoea pathogens: Cryptosporidium parvum, coronavirus, rotavirus, and E. coli.
Resource Centre

REFERENCES
1. Timmermans, M., Schroer, D., Hubers, W., Hermans, D., Vertenten, G., Roosmalen, M. Van, The first efficacious Cryptosporidium vaccine protecting newborn calves, Veterinary Vaccine 3 2024
2. Hubers, W., Gevers, K., Timmermans, M., Vertenten, G., van Roosmalen, M, Bovine anti-Gp40 antibodies neutralize Cryptosporidium infections in-vitro and are reactive with different Cryptosporidium stadia, European Buiatric Congress, 2023.
3. Berge AC, Besser TE, Moore DA, Sischo WM. Evaluation of the effects of oral colostrum supplementation during the first fourteen days on the health and performance of preweaned calves. J Dairy Sci. 2009 Jan;92(1):286-95. doi: 10.3168/jds.2008-1433. PMID: 19109287; PMCID: PMC7125711.
AVAILABLE ONLY UNDER VETERINARY AUTHORISATION ACVM No’s: Rotavec Corona A8132, Bovilis Cryptium A012159, Halocur A9802 , Schering-Plough Animal Health Ltd. Phone: 0800 800 543. www.msd-animal-health.co.nz. 2025 Merck & Co., Inc., Rahway, NJ, USA and its affiliates. All rights reserved. NZ-BOV-251100001



